LL-37 Research Guide
What Is LL-37?
LL-37 is a naturally occurring antimicrobial peptide and the only known human member of the cathelicidin family of antimicrobial peptides. It is produced through the processing of the precursor protein hCAP18 and consists of 37 amino acids, from which it derives its name.
Widely distributed throughout the body, LL-37 is expressed by a variety of cell types, including epithelial cells and immune cells. Its role within the innate immune system has made it one of the most extensively studied host defence peptides in modern biomedical research.
Its naturally occurring origin and broad biological significance continue to make LL-37 an important subject of scientific investigation.
Understanding How LL-37 Works
LL-37 is classified as an antimicrobial peptide and host defence peptide.
Researchers have investigated how LL-37 interacts with microorganisms, immune cells and cellular signalling pathways. Scientific literature has explored its role in innate immunity, inflammatory signalling, chemotaxis and tissue biology, making it one of the most widely researched peptides within immunology.
Because LL-37 participates in multiple biological systems, research continues across a wide range of scientific disciplines.
Why Researchers Study LL-37
LL-37 has been investigated across numerous areas of scientific research, including:
- Innate immunity
- Immunology
- Cellular signalling
- Host defence peptides
- Molecular biology
- Tissue biology
- Microbiology
Its naturally occurring role and extensive body of published literature continue to make LL-37 a significant subject of scientific investigation.
The Discovery of LL-37
LL-37 was identified as the active peptide produced from the precursor protein hCAP18.
Researchers subsequently discovered that LL-37 is the only human cathelicidin peptide and is expressed in numerous tissues throughout the body. Since its discovery, scientific interest has expanded considerably due to its diverse biological functions and involvement in innate immune responses.
Today, LL-37 remains one of the most extensively researched antimicrobial peptides.
What Makes LL-37 Different?
Unlike many synthetic research peptides, LL-37 occurs naturally within the human body.
It also differs from growth hormone peptides, neuropeptides and copper peptides because it belongs to the cathelicidin family of antimicrobial peptides and plays a recognised role within the innate immune system.
Its classification as a host defence peptide distinguishes LL-37 from many other research compounds.
LL-37 Compared to Other Research Peptides
LL-37
A naturally occurring cathelicidin antimicrobial peptide investigated within innate immunity and cellular signalling research.
KPV
A synthetic tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH) studied within cellular biology research.
GHK-Cu
A naturally occurring copper-binding peptide investigated within cellular signalling and tissue biology.
BPC-157
A synthetic peptide commonly investigated within tissue-related research.
Each compound possesses a distinct biological origin and area of scientific investigation.
Product Specifications
Compound: LL-37
Full Name: Human Cathelicidin Antimicrobial Peptide LL-37
Quantity: 5mg
Form: Lyophilised powder
Appearance: White to off-white powder
Storage: Store refrigerated upon receipt
Testing: Independently batch tested
Research Classification: Naturally Occurring Antimicrobial Peptide
Independent Batch Testing
At Platinum Peptides, transparency and quality assurance remain central to our approach.
Every batch undergoes independent third-party analytical testing to verify identity and purity before being released.
Why Batch Testing Matters
Identity Verification
Confirms that the material matches the labelled compound.
Purity Analysis
Provides confidence that the sample meets established quality standards.
Consistency
Helps ensure batch-to-batch reliability and reproducibility.
Transparency
Allows researchers to review independent analytical data before making purchasing decisions.
Certificates of Analysis are available for each batch where applicable.
Storage Information
Lyophilised peptides should be stored in a cool, dry environment and protected from excessive heat, moisture and direct sunlight.
Researchers should always review appropriate storage conditions relevant to their specific protocols and applications.
Frequently Asked Questions
What is LL-37?
LL-37 is a naturally occurring antimicrobial peptide and the only identified human member of the cathelicidin family.
What does LL-37 stand for?
The name LL-37 refers to the peptide's amino acid sequence, which begins with two leucine (L) residues, and its length of 37 amino acids.
Is LL-37 naturally occurring?
Yes. LL-37 is produced naturally within the human body through the processing of the precursor protein hCAP18.
What is a cathelicidin?
Cathelicidins are a family of antimicrobial peptides involved in innate immunity. LL-37 is the only cathelicidin identified in humans.
What type of peptide is LL-37?
LL-37 is classified as a naturally occurring antimicrobial peptide and host defence peptide.
Is LL-37 batch tested?
Yes. Platinum Peptides uses independent third-party testing to verify batch quality and purity.
How should LL-37 be stored?
Store in accordance with established peptide storage guidelines and maintain refrigeration where appropriate.
Related Research Compounds
Researchers interested in LL-37 may also wish to explore:
Important Information
This product is supplied strictly for laboratory research purposes only.
It is not intended for human consumption, therapeutic use, diagnostic use or veterinary use.
Researchers are responsible for ensuring compliance with all applicable laws, regulations and research protocols relating to the handling and use of peptide compounds.
Platinum Peptides does not provide guidance regarding dosage, administration, usage protocols or expected effects. Researchers are responsible for conducting their own independent research.